ISDA: 7MR8

Deposition Date 2021-05-07

Release Date 2022-05-11

Last Version Date 2026-07-29

Entry Detail

PDB ID:

7MR8

Keywords:

GENE REGULATION

Title:

Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-076

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.20 Å

R-Value Free:

0.17

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Bromodomain-containing protei
Gene (Uniprot):BRD4
Chain IDs:A
Chain Length:127
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O60885 Pfam ID:PF00439

Ligand Molecules

EDO

ZNJ

Primary Citation

Structural Basis for BD1-Preferring 2,4-Disubstituted Pyrimidine BRDT Inhibitors.

Liang, T, Guan, X, Chan, A, Kalra, P, Shi, R, Solberg, J, Sigua, L.H, Qi, J, Pomerantz, W.C.K, Schonbrunn, E, Hawkinson, J.E, Georg, G.I.Show

J.Med.Chem. 69 11088 11108 (2026)

PMID: 41984625 DOI: 10.1021/acs.jmedchem.6c00180

Primary Citation of related structures

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