9Y9K image
Deposition Date 2025-09-14
Release Date 2026-07-22
Last Version Date 2026-07-22
Entry Detail
PDB ID:
9Y9K
Keywords:
VIRAL PROTEIN
Title:
HIV-1 Nef SF2 Core Domain Bound To The Human Hck SH3 Domain
Biological Source:
Source Organism(s):
HIV-1 M:B_ARV2/SF2 (Taxon ID: 11685)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.34 Å
R-Value Free:
0.28
R-Value Work:
0.24
R-Value Observed:
0.24
Space Group:
P 41 21 2
9Y9K validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein Nef
Gene (Uniprot):nef
Chain IDs:A
Chain Length:149
Number of Molecules:1
Biological Source:HIV-1 M:B_ARV2/SF2
UniProt ID:P03407 Pfam ID:PF00469
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tyrosine-protein kinase HCK
Gene (Uniprot):HCK
Chain IDs:B
Chain Length:73
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P08631 Pfam ID:PF00018 EC:2.7.10.2
Ligand Molecules
EDO
NO3
Primary Citation
HIV-1 Nef Homodimerization as a Structural Mechanism for Kinase Activation and Small Molecule Inhibitor Action
To Be Published ? ? ? (?)
Primary Citation of related structures
9Y58
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