ISDA: 9Y7F

Deposition Date 2025-09-10

Release Date 2026-09-16

Last Version Date 2026-09-16

Entry Detail

PDB ID:

9Y7F

Keywords:

MEMBRANE PROTEIN

Title:

Crystal structure of nanobody R3D8 in complex with human voltage-gated sodium channel Nav1.7 P-loop 1.

Biological Source:

Source Organism(s):

Vicugna pacos (Taxon ID: 30538)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.70 Å

R-Value Free:

0.24

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Nanobody R3D8
Chain IDs:A
Chain Length:127
Number of Molecules:1
Biological Source:Vicugna pacos

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Sodium channel protein type 9
Gene (Uniprot):SCN9A
Mutagens:Y304C, Y305S
Chain IDs:B
Chain Length:31
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q15858

Primary Citation

Antigen-Detected NMR for Minimal Epitope Engineering and Structure-Guided Selection of a Na V 1.7-Selective Nanobody.

Liu, J, Chen, W, Cristofori-Armstrong, B, Crawford, T, Chen, K.E, Xie, P, Chan, R.W.B, Zhu, Y, Golder, M, Pereira Schmidt, A, Naughton, J.D, Condon, N.D, Andersson, A, Dehkhoda, F, McMahon, K.L, Klasfauseweh, T, Thapa, A, Tran, H, Tran, P, Jami, S, Ragnarsson, L, Furness, S.G.B, Deuis, J.R, Collins, B.M, Tham, W.H, Prasadam, I, Vetter, I, Mobli, M.Show

Adv Sci ? e77611 e77611 (2026)

PMID: 42702812 DOI: 10.1002/advs.77611

Primary Citation of related structures

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