ISDA: 9Y60

Deposition Date 2025-09-06

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

9Y60

Keywords:

TRANSFERASE

Title:

Crystal structure of NSD2 PWWP1 domain in complex with (6R)-6-(3,5-dichlorophenyl)morpholin-3-one (ligand 2)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.02 Å

R-Value Free:

0.27

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 43 21 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone-lysine N-methyltransf
Gene (Uniprot):NSD2
Chain IDs:A
Chain Length:174
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O96028 Pfam ID:PF00855 EC:2.1.1.356

Ligand Molecules

A1CSP

Primary Citation

NSD2 Degradation Remediates the Oncogenic Cistrome in t(4;14) Multiple Myeloma.

Hu, B, Edwards, J, Modi, H, Gamez, J, Echeagaray, O.E, Hess, K, Ren, Y, Anderson, D, Larrayoz, M, Zhu, J, Johnson, S.A, Deb, G, Jankeel, D, Janardhanan, P, Leisten, J, Peng, S, Christoforou, A, Stong, N, Fontanillo, C, Bjorklund, C.C, Hagner, P.R, Gandhi, A.K, Martinez-Climent, J.A, Narla, R.K, Lopez-Girona, A, Rolfe, M, Bence, N, Mortensen, D.S, Groocock, L.Show

Blood ? ? ? (2026)

PMID: 42371798 DOI: 10.1182/blood.2025031998

Primary Citation of related structures

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