9Y4L image
Deposition Date 2025-09-03
Release Date 2026-09-09
Last Version Date 2026-09-09
Entry Detail
PDB ID:
9Y4L
Keywords:
IMMUNE SYSTEM
Title:
CryoEM Structure of human MDA5 in complex with dsRNA (two protein subunits on dsRNA)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
in vitro transcription vector pT7-Fluc(deltai) (Taxon ID: 905932)
Expression System(s):
Escherichia coli 'bl21-gold(de3)plyss ag'
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.96 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9Y4L validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Interferon-induced helicase C
Gene (Uniprot):IFIH1
Chain IDs:A, B (auth: G)
Chain Length:728
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q9BYX4 Pfam ID:PF04851, PF18119, PF00271, PF11648 EC:3.6.4.13
Polymer Type:polyribonucleotide
Molecule:RNA (30-MER)
Chain IDs:C (auth: B)
Chain Length:30
Number of Molecules:1
Biological Source:in vitro transcription vector pT7-Fluc(deltai)
Polymer Type:polyribonucleotide
Molecule:RNA (30-MER)
Chain IDs:D (auth: C)
Chain Length:30
Number of Molecules:1
Biological Source:in vitro transcription vector pT7-Fluc(deltai)
Ligand Molecules
ANP
Primary Citation
Unraveling the molecular basis for MDA5 T331I disease-linked mutation
To Be Published ? ? ? (?)
Primary Citation of related structures
9Y4L
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