9XZ2 image
Deposition Date 2025-08-26
Release Date 2026-09-09
Last Version Date 2026-09-09
Entry Detail
PDB ID:
9XZ2
Keywords:
TRANSFERASE
Title:
Crystal structure of BTK kinase domain bound to a tirabrutinib analog with an acrylamide warhead
Biological Source:
Source Organism(s):
Mus musculus (Taxon ID: 10090)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.48 Å
R-Value Free:
0.28
R-Value Work:
0.23
R-Value Observed:
0.24
Space Group:
P 31
9XZ2 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tyrosine-protein kinase BTK
Gene (Uniprot):Btk
Mutagens:K430R, L542M S543T, V555T, R562K, S564A, P565S, Y617P
Chain IDs:A, B
Chain Length:271
Number of Molecules:2
Biological Source:Mus musculus
UniProt ID:P35991 Pfam ID:PF07714 EC:2.7.10.2
Ligand Molecules
A1CSB
Primary Citation
Crystal structure of BTK kinase domain bound to a tirabrutinib analog with an acrylamide warhead
To Be Published ? ? ? (?)
Primary Citation of related structures
9XYV
9XYY
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