9XJT image
Deposition Date 2025-11-05
Release Date 2026-11-11
Last Version Date 2026-11-11
Entry Detail
PDB ID:
9XJT
Keywords:
DNA BINDING PROTEIN
Title:
Crystal structure of human WDR5 in complex with Tasisulam
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli 'bl21-gold(de3)plyss ag'
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.38 Å
R-Value Free:
0.17
R-Value Work:
0.16
R-Value Observed:
0.16
Space Group:
C 2 2 21
9XJT validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:WD repeat-containing protein
Gene (Uniprot):WDR5
Chain IDs:A
Chain Length:304
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P61964
Ligand Molecules
P7M
Primary Citation
Dual Targeting of WDR5 and RBM39 Unveils a Promising Therapeutic Vulnerability in MYCN-Driven Neuroblastoma
To be published ? ? ? (?)
Primary Citation of related structures
9XJT
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