ISDA: 9XH8

Deposition Date 2025-10-31

Release Date 2026-11-04

Last Version Date 2026-11-04

Entry Detail

PDB ID:

9XH8

Keywords:

VIRAL PROTEIN/DNA

Title:

Cryo-EM structure of unnatural-base aptamer AptD1c with DENV1 NS1 tetramer

Biological Source:

Source Organism(s):

dengue virus type 1 (Taxon ID: 11053)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.69 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Non-structural protein 1
Gene (Uniprot):POLY
Chain IDs:A, B (auth: C), E (auth: B), F (auth: D)
Chain Length:370
Number of Molecules:4
Biological Source:dengue virus type 1

UniProt ID:A0A6B9QPG9

Polymer Type:polydeoxyribonucleotide
Molecule:unnatural-base aptamer AptD1c
Chain IDs:C (auth: E), D (auth: F)
Chain Length:70
Number of Molecules:2
Biological Source:synthetic construct

Ligand Molecules

NAG

Primary Citation

Structural Insights into Enhanced Binding Affinity and Specificity of Six-Letter DNA Aptamers to Dengue Antigen NS1 Proteins via Genetic Alphabet Expansion

Sawada, K, Kimoto, M, Matsunaga, K, Tan, H.P, Takayanagi, R, Sano, F.K, Shuto, Y, Hirano, H, Kusakizako, T, Itoh, Y, Kise, Y, Hirao, I, Nureki, O.Show

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Primary Citation of related structures

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