9X0J image
Deposition Date 2025-09-30
Release Date 2026-03-18
Last Version Date 2026-03-18
Entry Detail
PDB ID:
9X0J
Keywords:
CYTOKINE/IMMUNE SYSTEM
Title:
IL-33 and Etokimab fab and Tozorakimab fab ternary complex structure
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.57 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9X0J validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Interleukin-33 (109-270)
Gene (Uniprot):IL33
Chain IDs:A
Chain Length:158
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O95760 Pfam ID:PF15095
Polymer Type:polypeptide(L)
Molecule:Etokimab-K Chain
Chain IDs:E (auth: B)
Chain Length:214
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Tozorakimab-L Chain
Chain IDs:B (auth: C)
Chain Length:212
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Etokimab-H Chain
Chain IDs:D (auth: E)
Chain Length:221
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Tozorakimab-H Chain
Chain IDs:C (auth: F)
Chain Length:227
Number of Molecules:1
Biological Source:Homo sapiens
Ligand Molecules
NA
Primary Citation
Structures of clinical antibodies bound to IL-33 uncover two distinct epitopes underlying differential efficacy.
Mabs 18 2639673 2639673 (2026)
PMID: 41765683 DOI: 10.1080/19420862.2026.2639673
Primary Citation of related structures
9X0J
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