9X05 image
Deposition Date 2025-09-29
Release Date 2026-03-18
Last Version Date 2026-03-18
Entry Detail
PDB ID:
9X05
Keywords:
CYTOKINE/IMMUNE SYSTEM
Title:
IL-33 and Itepekimab fab and Tozorakimab fab ternary complex structure
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens, Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.64 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9X05 validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Interleukin-33 (109-270)
Gene (Uniprot):IL33
Chain IDs:D (auth: A)
Chain Length:158
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O95760 Pfam ID:PF15095
Polymer Type:polypeptide(L)
Molecule:Itepekimab-H chain
Chain IDs:A (auth: B)
Chain Length:221
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Tozorakimab-L chain
Chain IDs:B (auth: C)
Chain Length:212
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Tozorakimab-H chain
Chain IDs:E (auth: D)
Chain Length:227
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Itepekimab-K chain
Chain IDs:C (auth: E)
Chain Length:214
Number of Molecules:1
Biological Source:Homo sapiens
Ligand Molecules
NA
Primary Citation
Structures of clinical antibodies bound to IL-33 uncover two distinct epitopes underlying differential efficacy.
Mabs 18 2639673 2639673 (2026)
PMID: 41765683 DOI: 10.1080/19420862.2026.2639673
Primary Citation of related structures
9X05
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