ISDA: 9WYG

Deposition Date 2025-09-26

Release Date 2026-02-11

Last Version Date 2026-09-16

Entry Detail

PDB ID:

9WYG

Keywords:

VIRAL PROTEIN

Title:

Crystal structure of HAstV8 spike

Biological Source:

Source Organism(s):

Human astrovirus-8 (Taxon ID: 43358)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.44 Å

R-Value Free:

0.20

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

P 21 21 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Spike protein VP27
Gene (Uniprot):ORF2
Chain IDs:A
Chain Length:233
Number of Molecules:1
Biological Source:Human astrovirus-8

UniProt ID:Q9IFX1

Primary Citation

The conserved human astrovirus-receptor interface reveals a targetable vulnerability for antiviral development.

Wang, W, Xu, Y, Li, Z, Liu, D, Ma, K, Wang, R, Chen, R, Shu, B, Sun, X, Liu, Y, Ke, X, Zhang, S.Show

Nat Commun 17 ? ? (2026)

PMID: 41813687 DOI: 10.1038/s41467-026-70465-5

Primary Citation of related structures

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