ISDA: 9WY0

Deposition Date 2025-09-26

Release Date 2026-08-12

Last Version Date 2026-08-12

Entry Detail

PDB ID:

9WY0

Keywords:

OXIDOREDUCTASE

Title:

Crystal Structure of HIF-PHD2 in complex with compound 3-1

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.80 Å

R-Value Free:

0.22

R-Value Work:

0.19

R-Value Observed:

0.20

Space Group:

P 41

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Egl nine homolog 1
Chain IDs:A
Chain Length:224
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

A1MCC

FE2

Primary Citation

Discovery of DS79540454 via fragment-based drug discovery strategy: New scaffolds of hypoxia-inducible factor prolyl hydroxylase inhibitor.

Fukuda, T, Nishi, T, Ishiyama, T, Kitazawa, R, Ishii, K, Takahashi, S, Kawabata, Y, Yamaguchi, K, Baba, D, Ito, S, Tanaka, N.Show

Bioorg.Med.Chem.Lett. 131 130476 130476 (2026)

PMID: 41265580 DOI: 10.1016/j.bmcl.2025.130476

Primary Citation of related structures

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