9WWH image
Deposition Date 2025-09-23
Release Date 2026-03-18
Last Version Date 2026-03-18
Entry Detail
PDB ID:
9WWH
Keywords:
CYTOKINE/IMMUNE SYSTEM
Title:
Crystal structure of IL-33 and antibody Tozorakimab fab binary complex
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens, Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
3.51 Å
R-Value Free:
0.25
R-Value Work:
0.22
R-Value Observed:
0.23
Space Group:
P 21 21 21
9WWH validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Interleukin-33 (109-270)
Gene (Uniprot):IL33
Chain IDs:E (auth: C), F (auth: D)
Chain Length:152
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:O95760 Pfam ID:PF15095
Polymer Type:polypeptide(L)
Molecule:Tozorakimab-Heavy chain
Chain IDs:A (auth: H), C (auth: A)
Chain Length:228
Number of Molecules:2
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Tozorakimab-Light chain
Chain IDs:B (auth: L), D (auth: B)
Chain Length:211
Number of Molecules:2
Biological Source:Homo sapiens
Ligand Molecules
NA
Primary Citation
Structures of clinical antibodies bound to IL-33 uncover two distinct epitopes underlying differential efficacy.
Mabs 18 2639673 2639673 (2026)
PMID: 41765683 DOI: 10.1080/19420862.2026.2639673
Primary Citation of related structures
9WWH
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