ISDA: 9WGO

Deposition Date 2025-08-25

Release Date 2026-05-20

Last Version Date 2026-05-20

Entry Detail

PDB ID:

9WGO

Keywords:

HYDROLASE

Title:

Crystal structure of OcKAI2d2 from Orobanche cumana covalently bound to KOK1094

Biological Source:

Source Organism(s):

Orobanche cernua var. cumana (Taxon ID: 78542)

Expression System(s):

Escherichia coli 'bl21-gold(de3)plyss ag'

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.35 Å

R-Value Free:

0.24

R-Value Work:

0.21

R-Value Observed:

0.22

Space Group:

P 64 2 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:OcKAI2d2 protein
Chain IDs:A
Chain Length:277
Number of Molecules:1
Biological Source:Orobanche cernua var. cumana

UniProt ID:9WGO

Ligand Molecules

A1MBM

Primary Citation

Orobanche cumana KAI2d2 mediates perception of dehydrocostus lactone and strigolactones and is inhibited by triazole ureas.

Shahul Hameed, U.F, Jamil, M, Zarban, R, Saito, Y, Alashoor, K, Balakrishna, A, Asami, T, Arold, S.T, Al-Babili, S.Show

Plant Commun. ? 101889 101889 (2026)

PMID: 42104616 DOI: 10.1016/j.xplc.2026.101889

Abstact

Seed germination of the parasitic plant Orobanche cumana is induced by host-derived strigolactones and dehydrocostus lactone. We show that the KAI2d2 receptor perceives both ligands through distinct modes of interaction. Triazole urea compounds covalently inhibit KAI2d receptors, suppressing germination without affecting sunflower growth.

Legend

Protein

Chemical

Disease

Primary Citation of related structures

Abstact

Feedback Form