ISDA: 9WGN

Deposition Date 2025-08-25

Release Date 2026-05-20

Last Version Date 2026-05-20

Entry Detail

PDB ID:

9WGN

Keywords:

HYDROLASE

Title:

Crystal structure of Orobanche cumana OcKAI2d2 covalently bound to KOK1007

Biological Source:

Source Organism(s):

Orobanche cernua var. cumana (Taxon ID: 78542)

Expression System(s):

Escherichia coli 'bl21-gold(de3)plyss ag'

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.40 Å

R-Value Free:

0.17

R-Value Work:

0.14

R-Value Observed:

0.14

Space Group:

P 32 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Alpha/beta-hydrolases superfa
Chain IDs:A
Chain Length:277
Number of Molecules:1
Biological Source:Orobanche cernua var. cumana

UniProt ID:A0A2U8XPZ9

Ligand Molecules

A1MBO

Primary Citation

Orobanche cumana KAI2d2 mediates perception of dehydrocostus lactone and strigolactones and is inhibited by triazole ureas.

Shahul Hameed, U.F, Jamil, M, Zarban, R, Saito, Y, Alashoor, K, Balakrishna, A, Asami, T, Arold, S.T, Al-Babili, S.Show

Plant Commun. ? 101889 101889 (2026)

PMID: 42104616 DOI: 10.1016/j.xplc.2026.101889

Abstact

Seed germination of the parasitic plant Orobanche cumana is induced by host-derived strigolactones and dehydrocostus lactone. We show that the KAI2d2 receptor perceives both ligands through distinct modes of interaction. Triazole urea compounds covalently inhibit KAI2d receptors, suppressing germination without affecting sunflower growth.

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Protein

Chemical

Disease

Primary Citation of related structures

Abstact

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