ISDA: 9W8S

Deposition Date 2025-08-08

Release Date 2026-06-24

Last Version Date 2026-06-24

Entry Detail

PDB ID:

9W8S

Keywords:

TRANSCRIPTION

Title:

Structure of mammalian RNA polymerase II stalled by a cisplatin-induced inter-strand crosslink lesion at the +2 position.

Biological Source:

Source Organism(s):

synthetic construct (Taxon ID: 32630)
Sus scrofa (Taxon ID: 9823)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.04 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase I
Chain IDs:A
Chain Length:1970
Number of Molecules:1
Biological Source:Sus scrofa

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase s
Gene (Uniprot):POLR2B
Chain IDs:B
Chain Length:1174
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:I3LGP4 Pfam ID:PF04563, PF04561, PF04565, PF04566, PF04567, PF00562, PF04560 EC:2.7.7.6

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase I
Gene (Uniprot):POLR2C
Chain IDs:C
Chain Length:271
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:I3LCH3 Pfam ID:PF01193, PF01000

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase I
Chain IDs:D
Chain Length:142
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A481BYI6

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerases
Gene (Uniprot):POLR2E
Chain IDs:E
Chain Length:210
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:I3LSI7 Pfam ID:PF03871, PF01191

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerases
Gene (Uniprot):POLR2F
Chain IDs:F
Chain Length:127
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A4X1VEK9 Pfam ID:PF01192

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase s
Chain IDs:G
Chain Length:171
Number of Molecules:1
Biological Source:Sus scrofa

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerases
Gene (Uniprot):POLR2H
Chain IDs:H
Chain Length:150
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:I3LCB2 Pfam ID:PF03870

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase I
Gene (Uniprot):POLR2I
Chain IDs:I
Chain Length:125
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:P60899 Pfam ID:PF02150, PF01096

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerases
Gene (Uniprot):POLR2L
Chain IDs:J
Chain Length:67
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A4X1VYD0

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerase I
Gene (Uniprot):POLR2J
Chain IDs:K
Chain Length:115
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:F1RKE4 Pfam ID:PF13656

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-directed RNA polymerases
Gene (Uniprot):POLR2K
Chain IDs:L
Chain Length:58
Number of Molecules:1
Biological Source:Sus scrofa

UniProt ID:A0A4X1TRS6 Pfam ID:PF03604

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (NTS, non-template strand
Chain IDs:M (auth: N)
Chain Length:18
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(*UP*AP*CP*AP*AP*UP*
Chain IDs:N (auth: P)
Chain Length:20
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (TS, template strand)
Chain IDs:O (auth: T)
Chain Length:25
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules