9W6A image
Deposition Date 2025-08-03
Release Date 2026-08-05
Last Version Date 2026-08-05
Entry Detail
PDB ID:
9W6A
Keywords:
IMMUNE SYSTEM
Title:
Crystal structure of 18-3 TCR in complex with HLA-A*11:01 bound to HPV16-E6(93-101)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)
Human papillomavirus 16 (Taxon ID: 333760)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.35 Å
R-Value Free:
0.23
R-Value Work:
0.19
R-Value Observed:
0.19
Space Group:
C 1 2 1
9W6A validation report missing
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:18-3 TCR alpha chain
Chain IDs:D (auth: A)
Chain Length:201
Number of Molecules:1
Biological Source:Mus musculus
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:18-3 TCR beta chain
Chain IDs:E (auth: B)
Chain Length:242
Number of Molecules:1
Biological Source:Mus musculus
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:MHC class I antigen
Gene (Uniprot):HLA-A
Chain IDs:A (auth: C)
Chain Length:275
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:A0A6M6CC39
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Beta-2-microglobulin
Gene (Uniprot):B2M
Chain IDs:B (auth: D)
Chain Length:99
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P61769 Pfam ID:PF07654
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein E6
Gene (Uniprot):E6
Chain IDs:C (auth: E)
Chain Length:9
Number of Molecules:1
Biological Source:Human papillomavirus 16
UniProt ID:P03126
Primary Citation
Harnessing CD8 co-receptor dependency of HPV-E6 specific TCR for tumor immunotherapy
To Be Published ? ? ? (?)
Primary Citation of related structures
9W6A
Feedback Form
Name
Email
Institute
Feedback