ISDA: 9W5A

Deposition Date 2025-08-01

Release Date 2026-04-29

Last Version Date 2026-04-29

Entry Detail

PDB ID:

9W5A

Keywords:

HYDROLASE

Title:

The structure of dUTPase in complex with dUTP from Methanosarcina mazei

Biological Source:

Source Organism(s):

Methanosarcina mazei (Taxon ID: 2209)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.53 Å

R-Value Free:

0.20

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

P 43

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Probable deoxyuridine 5'-trip
Chain IDs:A, B, C
Chain Length:183
Number of Molecules:3
Biological Source:Methanosarcina mazei

UniProt ID:Q8PWG1

Ligand Molecules

DUT

PO4

Primary Citation

Structural and functional insights into an archaeal dUTPase reveal a subdomain-mediated mechanism for substrate recognition and evolutionary adaptation.

Chen, S.C, Chou, C.C, Chen, W.M, Sheu, S.Y, Huang, L.W, Huang, C.H, Chang, S.C, Kuo, C.H, Hsu, C.H.Show

Int.J.Biol.Macromol. 335 149194 149194 (2026)

PMID: 41308777 DOI: 10.1016/j.ijbiomac.2025.149194

Primary Citation of related structures

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