9W3F image
Deposition Date 2025-07-29
Release Date 2026-06-10
Last Version Date 2026-06-10
Entry Detail
PDB ID:
9W3F
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of the human beta2-adrenergic receptor in complex with a novel antagonist
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Enterobacteria phage T4 (Taxon ID: 10665)
Lama glama (Taxon ID: 9844)
Expression System(s):
Spodoptera, Escherichia coli 'bl21-gold(de3)plyss ag'
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.04 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9W3F validation report missing
Macromolecular Entities
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Beta-2 adrenergic receptor,En
Gene (Uniprot):E, ADRB2
Chain IDs:A
Chain Length:517
Number of Molecules:1
Biological Source:Homo sapiens, Enterobacteria phage T4
UniProt ID:P07550,P00720 Pfam ID:PF00001, PF00959 EC:3.2.1.17
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Beta2 adrenogic receptor inac
Chain IDs:B
Chain Length:125
Number of Molecules:1
Biological Source:Lama glama
Ligand Molecules
BER
Primary Citation
A negative survival pressure selection system enables GPCR antagonist screening.
Cell Discov 12 ? ? (2026)
PMID: 42129146 DOI: 10.1038/s41421-026-00892-7
Primary Citation of related structures
9W3F
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