9W0W image
Deposition Date 2025-07-24
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
9W0W
Keywords:
MEMBRANE PROTEIN
Title:
CryoEM structure of the T2R46 in complex with strychine and heterotrimeric G protein complex
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.20 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9W0W validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI1
Mutagens:S47N,G202T,G203A,E245A,A326S
Chain IDs:B (auth: A)
Chain Length:354
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P63096 Pfam ID:PF00503
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:C (auth: B)
Chain Length:351
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62873 Pfam ID:PF25391
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:D (auth: C)
Chain Length:71
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P59768 Pfam ID:PF00631
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Taste receptor type 2 member
Gene (Uniprot):TAS2R46
Chain IDs:A (auth: R)
Chain Length:363
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P59540 Pfam ID:PF05296
Ligand Molecules
SY9
Primary Citation
Ligand binding modes of the bitter taste receptor T2R14 and T2R46
Nat. Struct. Mol. Biol. ? ? ? (2026)
DOI: 10.1038/s41594-026-01786-8
Primary Citation of related structures
9W0W
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