9W0Q image
Deposition Date 2025-07-24
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
9W0Q
Title:
Cryo-EM structure of T2R14 in complex with tangeretin and heterotrimeric G protein
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Escherichia coli (Taxon ID: 562)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
3.20 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI1
Chain IDs:A
Chain Length:354
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:B
Chain Length:351
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:C
Chain Length:71
Number of Molecules:1
Biological Source:Homo sapiens
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Soluble cytochrome b562,Taste
Gene (Uniprot):cybC, TAS2R14
Chain IDs:D (auth: R)
Chain Length:483
Number of Molecules:1
Biological Source:Escherichia coli, Homo sapiens
Ligand Molecules
Primary Citation
Ligand binding modes of the bitter taste receptor T2R14 and T2R46
Nat. Struct. Mol. Biol. ? ? ? (2026)
DOI: 10.1038/s41594-026-01786-8
Primary Citation of related structures
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