ISDA: 9W0L

Deposition Date 2025-07-24

Release Date 2026-06-03

Last Version Date 2026-06-03

Entry Detail

PDB ID:

9W0L

Keywords:

MEMBRANE PROTEIN

Title:

S1P3 in complex with CYM52581 and spm242

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Niallia circulans (Taxon ID: 1397)

Expression System(s):

Puma concolor

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.60 Å

R-Value Free:

0.28

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

C 2 2 21

Download Validation Report

Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Sphingosine 1-phosphate recep
Gene (Uniprot):xlnA, S1PR3
Chain IDs:A
Chain Length:484
Number of Molecules:1
Biological Source:Homo sapiens, Niallia circulans

UniProt ID:Q99500,P09850 Pfam ID:PF00001 EC:3.2.1.8

Ligand Molecules

A1EUC

A1EUD

Primary Citation

Structural basis of allosteric and bitopic ligands binding in sphingosine-1-phosphate receptors 2 and 3.

Wu, Y, Chen, Q, Wang, H, Liu, K, Wei, J, Wang, M, Chen, K, Zhu, Y, Han, S, Yi, C, Ma, L, Schnapp, G, Pautsch, A, Gnamm, C, Grauert, M, Schmidt, E, Tan, Q, Wu, B, Zhao, Q.Show

Protein Cell ? ? ? (2025)

PMID: 40851516 DOI: 10.1093/procel/pwaf068

Primary Citation of related structures

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