9W01 image
Deposition Date 2025-07-23
Release Date 2026-07-29
Last Version Date 2026-07-29
Entry Detail
PDB ID:
9W01
Keywords:
TRANSLATION
Title:
Cryo-EM structure of LARS1:IARS1 complex
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.16 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9W01 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Leucine--tRNA ligase, cytopla
Gene (Uniprot):LARS1
Chain IDs:A
Chain Length:1176
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9P2J5 Pfam ID:PF00133, PF08264, PF24810, PF22947 EC:6.1.1.4
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoleucine--tRNA ligase, cyto
Gene (Uniprot):IARS1
Chain IDs:B
Chain Length:1263
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P41252 Pfam ID:PF00133, PF08264, PF19302, PF23567 EC:6.1.1.5
Ligand Molecules
NA
Primary Citation
Cryo-EM structure of the LARS1:IARS1 complex reveals a nutrient-responsive switch controlling mTORC1 signaling.
Nat Commun ? ? ? (2026)
PMID: 42276995 DOI: 10.1038/s41467-026-74085-x
Primary Citation of related structures
9W01
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