ISDA: 9VRA

Deposition Date 2025-07-06

Release Date 2026-11-11

Last Version Date 2026-11-11

Entry Detail

PDB ID:

9VRA

Keywords:

RNA BINDING PROTEIN

Title:

Small molecule 2-60 targeting YTHDC1

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.49 Å

R-Value Free:

0.28

R-Value Work:

0.25

R-Value Observed:

0.25

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:YTH domain-containing protein
Gene (Uniprot):YTHDC1
Chain IDs:A, B
Chain Length:187
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q96MU7

Ligand Molecules

A1ES8

SO4

Primary Citation

AS-TLC-Based High-Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor.

Wang, M, Fu, S, Xu, Y, Gao, J, Ren, J, Yang, X, Xu, H, Sun, G, Li, Y, Wang, Y, Jin, L, Chen, P, Xu, Y, Li, J, Lin, H, Hu, C, Chen, K, Xiong, H, Luo, C, Chen, S.Show

Adv Sci ? e77386 e77386 (2026)

PMID: 42658481 DOI: 10.1002/advs.77386

Primary Citation of related structures

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