ISDA: 9VJO

Deposition Date 2025-06-21

Release Date 2026-06-24

Last Version Date 2026-08-05

Entry Detail

PDB ID:

9VJO

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of TRP melastatin channel in the intermediate 1 state

Biological Source:

Source Organism(s):

Mus musculus (Taxon ID: 10090)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.82 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Transient receptor potential
Gene (Uniprot):Trpm8
Chain IDs:A, B (auth: C), C (auth: D), D (auth: B)
Chain Length:1118
Number of Molecules:4
Biological Source:Mus musculus

UniProt ID:Q8R4D5 Pfam ID:PF18139, PF25508, PF00520

Ligand Molecules

PIO

Primary Citation

Symmetry-driven gating of TRPM8 by PIP 2 and menthol.

Kim, S.H, Hong, C, Park, H, Ju, Y, Hwang, Y, Kim, J, Ji, S, Yu, W, So, I, Lee, H.H.Show

Nat Commun 17 ? ? (2026)

PMID: 42481499 DOI: 10.1038/s41467-026-75793-0

Primary Citation of related structures

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