ISDA: 9VCS

Deposition Date 2025-06-06

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

9VCS

Keywords:

TOXIN

Title:

Cryo-EM structure of semi-closed state of Botulinum neurotoxin serotype A at pH 7.4

Biological Source:

Source Organism(s):

Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) (Taxon ID: 441771)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.80 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Botulinum neurotoxin type A
Gene (Uniprot):botA
Chain IDs:A
Chain Length:1308
Number of Molecules:1
Biological Source:Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)

UniProt ID:P0DPI1 Pfam ID:PF01742, PF07952, PF07953, PF07951 EC:3.4.24.69

Ligand Molecules

Primary Citation

Cryo-EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits.

Wang, W, Zerang, Z, You, L, Liu, Z, Nie, R, Qi, F, Gao, F, Zhao, C, Ma, W, He, J, Wang, X, Wu, S, Liu, B, Liu, X, Lei, D, Zhi, D, Wang, D.Show

Adv Sci ? e16713 e16713 (2026)

PMID: 41944347 DOI: 10.1002/advs.202516713

Primary Citation of related structures

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