ISDA: 9V7S

Deposition Date 2025-05-28

Release Date 2026-04-15

Last Version Date 2026-04-15

Entry Detail

PDB ID:

9V7S

Keywords:

RNA BINDING PROTEIN/DNA/RNA

Title:

Structure of the Argonaute protein from Verrucomicrobia bacterium in complex with guide DNA and target RNA

Biological Source:

Source Organism(s):

Verrucomicrobiota bacterium (Taxon ID: 2026799)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.50 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:VbAgo-DM
Mutagens:D550A/D617A
Chain IDs:A, D (auth: a)
Chain Length:782
Number of Molecules:2
Biological Source:Verrucomicrobiota bacterium

UniProt ID:9V7S

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(P*TP*GP*AP*GP*GP*TP
Chain IDs:B, E (auth: b)
Chain Length:18
Number of Molecules:2
Biological Source:Verrucomicrobiota bacterium

Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(*UP*AP*UP*AP*CP*AP*
Chain IDs:C, F (auth: c)
Chain Length:19
Number of Molecules:2
Biological Source:Verrucomicrobiota bacterium

Ligand Molecules

Primary Citation

Structural insights into C-terminus-mediated RNA target cleavage by a mesophilic prokaryotic argonaute.

Chen, T, Tao, X, Li, S, Duanmu, Q, Wang, J, Chen, K, Mu, K, Yang, H, Li, Y, Liu, Y, Ma, L, Wu, S.Show

Nat Commun ? ? ? (2026)

PMID: 41932907 DOI: 10.1038/s41467-026-71422-y

Primary Citation of related structures

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