ISDA: 9UP7

Deposition Date 2025-04-27

Release Date 2026-01-21

Last Version Date 2026-08-05

Entry Detail

PDB ID:

9UP7

Keywords:

IMMUNE SYSTEM

Title:

anti-HPV18 E7 monoclonal antibody

Biological Source:

Source Organism(s):

Mus musculus (Taxon ID: 10090)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.10 Å

R-Value Free:

0.25

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Heavy chain of the anti-HPV18
Chain IDs:A, C (auth: H)
Chain Length:214
Number of Molecules:2
Biological Source:Mus musculus

Polymer Type:polypeptide(L)
Molecule:Light chain of the anti-HPV18
Chain IDs:B, D (auth: L)
Chain Length:220
Number of Molecules:2
Biological Source:Mus musculus

Primary Citation

An mRNA-encoded scFv antibody targeting the helix-alpha 3 of HPV18 E7 oncoprotein as a novel antiviral strategy.

Han, F, Guo, X.y, Cui, L.y, Zhang, M.x, Zeng, Y.r, Wang, G.q, Li, J.j, Chi, X, Jiang, M.x, Xiong, Y.t, Zhou, L.z, Zheng, Q.b, Yu, H, Zhang, J, Li, T.t, Gu, Y, Xia, N.s, Li, S.Show

Mbio 17 e0262725 e0262725 (2026)

PMID: 41627058 DOI: 10.1128/mbio.02627-25

Primary Citation of related structures

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