ISDA: 9UNY

Deposition Date 2025-04-24

Release Date 2026-07-29

Last Version Date 2026-08-12

Entry Detail

PDB ID:

9UNY

Keywords:

OXIDOREDUCTASE

Title:

Natural product inhibitor of glyceraldehyde-3-phosphate dehydrogenase(GAPDH)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.87 Å

R-Value Free:

0.28

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glyceraldehyde-3-phosphate de
Gene (Uniprot):GAPDH
Chain IDs:A (auth: P), B (auth: A), C (auth: B), D (auth: C)
Chain Length:335
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P04406 Pfam ID:PF00044, PF02800 EC:1.2.1.12

Ligand Molecules

A1EP4

ACT

ARF

EPE

Primary Citation

GAPDH inhibition by oridonin integrates glycolytic inhibition and anti-inflammation to alleviate rheumatoid arthritis synovitis.

Xiao, Q, Zhou, H, Li, M, Peng, Y, Huang, Y, Zhao, Y, Chen, S, Chen, H, Zhang, C, Yuan, Q, Qiu, L, He, Y, Dai, Z, Peng, T, Fu, Q.Show

Phytomedicine 160 158650 158650 (2026)

PMID: 42542052 DOI: 10.1016/j.phymed.2026.158650

Primary Citation of related structures

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