9UIP image
Deposition Date 2025-04-16
Release Date 2026-10-28
Last Version Date 2026-10-28
Entry Detail
PDB ID:
9UIP
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of the human NK1 tachykinin receptor bound to the antagonist aprepitant resolved via the fusion/crosslinking strategy
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Aequorea victoria (Taxon ID: 6100)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.85 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9UIP validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Substance-P receptor
Gene (Uniprot):TACR1
Chain IDs:A
Chain Length:354
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P25103
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Green fluorescent protein
Gene (Uniprot):gfp
Chain IDs:B
Chain Length:196
Number of Molecules:1
Biological Source:Aequorea victoria
UniProt ID:A0A059PIQ0
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:GFP-clamp E186C
Chain IDs:C
Chain Length:294
Number of Molecules:1
Biological Source:synthetic construct
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
CRO B THR chromophore
Ligand Molecules
GBQ
Primary Citation
Cryo-EM structure determination of GPCRs with disulfide-crosslinked fusion protein
To Be Published ? ? ? (?)
Primary Citation of related structures
9UIP
Feedback Form
Name
Email
Institute
Feedback