9UHX image
Deposition Date 2025-04-14
Release Date 2026-10-28
Last Version Date 2026-10-28
Entry Detail
PDB ID:
9UHX
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of the human adenosine A2A receptor bound to the antagonist ZM-241385 resolved via the fusion/crosslinking strategy
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Aequorea victoria (Taxon ID: 6100)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.03 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9UHX validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Adenosine receptor A2a
Gene (Uniprot):ADORA2A
Chain IDs:A
Chain Length:331
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P29274
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Green fluorescent protein
Gene (Uniprot):gfp
Chain IDs:B
Chain Length:196
Number of Molecules:1
Biological Source:Aequorea victoria
UniProt ID:A0A059PIQ0
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:GFP-clamp
Chain IDs:C
Chain Length:294
Number of Molecules:1
Biological Source:synthetic construct
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
CRO B THR chromophore
Ligand Molecules
ZMA
Primary Citation
Cryo-EM structure determination of GPCRs with disulfide-crosslinked fusion protein
To Be Published ? ? ? (?)
Primary Citation of related structures
9UHX
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