ISDA: 9UEK

Deposition Date 2025-04-08

Release Date 2026-09-16

Last Version Date 2026-09-16

Entry Detail

PDB ID:

9UEK

Keywords:

OXIDOREDUCTASE

Title:

Cryo-EM structure of L-lysine 6-dehydrogenase complex with NAD+ and L-lysine

Biological Source:

Source Organism(s):

Geobacillus stearothermophilus (Taxon ID: 1422)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.53 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Lysine 6-dehydrogenase
Gene (Uniprot):lysDH
Chain IDs:A, B, C, D
Chain Length:384
Number of Molecules:4
Biological Source:Geobacillus stearothermophilus

UniProt ID:Q9AJC6 EC:1.4.1.18

Ligand Molecules

LYS

NAD

Primary Citation

Structural basis for substrate recognition in l-lysine 6-dehydrogenase from Geobacillus stearothermophilus by Cryo-EM.

Funahashi, T, Yamaguchi, H, Suzuki, S, Suzuki, H, Nishikawa, K, Takahashi, K, Tatsumi, M, Mizukoshi, T, Miyano, H, Fujiyoshi, Y, Sugiki, M.Show

J.Struct.Biol. 218 108366 108366 (2026)

PMID: 42665198 DOI: 10.1016/j.jsb.2026.108366

Primary Citation of related structures

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