9UBG image
Deposition Date 2025-04-03
Release Date 2025-05-07
Last Version Date 2026-10-14
Entry Detail
PDB ID:
9UBG
Keywords:
LIGASE
Title:
Cryo-EM structure of Pyruvate carboxylase from Mycobacterium tuberculosis in complex with Acetyl-CoA and ADP
Biological Source:
Source Organism(s):
Mycobacterium tuberculosis H37Rv (Taxon ID: 83332)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.70 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9UBG validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Pyruvate carboxylase
Gene (Uniprot):pca
Chain IDs:A, B (auth: C), C (auth: D), D (auth: B)
Chain Length:1045
Number of Molecules:4
Biological Source:Mycobacterium tuberculosis H37Rv
UniProt ID:I6YEU0 Pfam ID:PF02785, PF00289, PF02786, PF00682, PF02436 EC:6.4.1.1
Ligand Molecules
ACO
ADP
ZN
Primary Citation
Cryo-EM structures of Mycobacterium tuberculosis pyruvate carboxylase reveal acetyl-CoA-mediated tetramer stabilization and carrier-domain coordination
Commun Biol ? ? ? (2026)
DOI: 10.1038/s42003-026-11105-y
Primary Citation of related structures
9UBG
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