9TXL image
Deposition Date 2026-01-15
Release Date 2026-09-23
Last Version Date 2026-09-23
Entry Detail
PDB ID:
9TXL
Keywords:
IMMUNE SYSTEM
Title:
ITIH4N:MASP-1cf:12A12 F(ab) 2:1:2 complex (Composite)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.30 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9TXL validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoform 3 of Inter-alpha-tryp
Gene (Uniprot):ITIH4
Chain IDs:A, B
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q14624 Pfam ID:PF08487, PF00092
Polymer Type:polypeptide(L)
Molecule:Ligand glutamate from MASP-1c
Chain IDs:C
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:12A12 mAb F(ab) heavy chain
Chain IDs:D, F
Chain Length:0
Number of Molecules:2
Biological Source:Mus musculus
Polymer Type:polypeptide(L)
Molecule:12A12 mAb F(ab) light chain
Chain IDs:E, G
Chain Length:0
Number of Molecules:2
Biological Source:Mus musculus
Ligand Molecules
MG
NAG
Primary Citation
The plasma protease inhibitor ITIH4 forms oligomeric complexes and senses broader, proteolytic activity
To Be Published ? ? ? (?)
Primary Citation of related structures
9TXL
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