9TXJ image
Deposition Date 2026-01-15
Release Date 2026-09-23
Last Version Date 2026-09-23
Entry Detail
PDB ID:
9TXJ
Keywords:
IMMUNE SYSTEM
Title:
Cryo-EM structure of native ITIH4 with 12A12 F(ab)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.10 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9TXJ validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Isoform 3 of Inter-alpha-tryp
Gene (Uniprot):ITIH4
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q14624 Pfam ID:PF08487, PF00092, PF06668
Polymer Type:polypeptide(L)
Molecule:12A12 mAb F(ab) heavy chain
Chain IDs:B (auth: D)
Chain Length:0
Number of Molecules:1
Biological Source:Mus musculus
Polymer Type:polypeptide(L)
Molecule:12A12 mAb F(ab) light chain
Chain IDs:C (auth: E)
Chain Length:0
Number of Molecules:1
Biological Source:Mus musculus
Ligand Molecules
NA
Primary Citation
The plasma protease inhibitor ITIH4 forms oligomeric complexes and senses broader, proteolytic activity
To Be Published ? ? ? (?)
Primary Citation of related structures
9TXJ
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