ISDA: 9TSM

Deposition Date 2025-12-30

Release Date 2026-05-13

Last Version Date 2026-05-13

Entry Detail

PDB ID:

9TSM

Keywords:

TRANSCRIPTION

Title:

ProteinMPNN mutated PF3D7_1475600 (PfBDP4-BRD, 77.8% sequence identity) in complex with GSK9311

Biological Source:

Source Organism(s):

Plasmodium falciparum (Taxon ID: 5833)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.25 Å

R-Value Free:

0.13

R-Value Work:

0.10

R-Value Observed:

0.11

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Bromodomain protein, putative
Gene (Uniprot):PF3D7_1475600
Chain IDs:A
Chain Length:119
Number of Molecules:1
Biological Source:Plasmodium falciparum

UniProt ID:Q8IK82 Pfam ID:PF00439

Ligand Molecules

8VI

BU3

EDO

Primary Citation

Stabilizing Plasmodium falciparum proteins for small molecule drug discovery.

Amann, M, Strasser, T, Einsle, O, Gunther, S.Show

Protein Sci. 35 e70614 e70614 (2026)

PMID: 42068230 DOI: 10.1002/pro.70614

Primary Citation of related structures

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