ISDA: 9TO8

Deposition Date 2025-12-16

Release Date 2026-10-28

Last Version Date 2026-10-28

Entry Detail

PDB ID:

9TO8

Keywords:

ANTIMICROBIAL PROTEIN

Title:

Room temperature serial crystal structure of CTX-M-15 class A beta-lactamase, drop on fixed target from DLS, 1.3 s mixed with 50 mM avibactam

Biological Source:

Source Organism(s):

Klebsiella pneumoniae (Taxon ID: 573)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.76 Å

R-Value Free:

0.20

R-Value Work:

0.15

R-Value Observed:

0.16

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Beta-lactamase
Gene (Uniprot):blaCTX-M-15
Chain IDs:A
Chain Length:265
Number of Molecules:1
Biological Source:Klebsiella pneumoniae

UniProt ID:G3G192 EC:3.5.2.6

Ligand Molecules

NXL

Primary Citation

Time-resolved ligand dynamics revealed in a beta-lactamase using room-temperature serial crystallography

Parkinson, L, Tooke, C.L, Hinchliffe, P, Beer, M, Orville, A.M, Spencer, J.Show

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