ISDA: 9TMR

Deposition Date 2025-12-15

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9TMR

Keywords:

TRANSFERASE

Title:

Crystal structure of M. tuberculosis PknA in complex with Staurosporine

Biological Source:

Source Organism(s):

Mycobacterium tuberculosis (Taxon ID: 1773)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.90 Å

R-Value Free:

0.27

R-Value Work:

0.24

R-Value Observed:

0.24

Space Group:

I 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Gene (Uniprot):pknA
Chain IDs:A
Chain Length:284
Number of Molecules:1
Biological Source:Mycobacterium tuberculosis

UniProt ID:P9WI83 Pfam ID:PF00069 EC:2.7.11.1

Ligand Molecules

SO4

STU

Primary Citation

Structural insights into multitargeting Mycobacterium tuberculosis Pkn kinases.

Pollaniemi, A, Miao, Y, Laitila, L, Piippo, H, Hammaren, M, Parikka, M, Haikarainen, T.Show

Microbiol Spectr ? e0004926 e0004926 (2026)

PMID: 42446239 DOI: 10.1128/spectrum.00049-26

Primary Citation of related structures

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