ISDA: 9TM5

Deposition Date 2025-12-12

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9TM5

Keywords:

TRANSFERASE

Title:

Crystal structure of JAK2 JH1 in complex with AT9283

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.45 Å

R-Value Free:

0.19

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Tyrosine-protein kinase JAK2
Gene (Uniprot):JAK2
Chain IDs:A
Chain Length:316
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O60674 Pfam ID:PF07714 EC:2.7.10.2

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
PTR	A	TYR	modified residue

Ligand Molecules

35R

Primary Citation

Structural insights into multitargeting Mycobacterium tuberculosis Pkn kinases.

Pollaniemi, A, Miao, Y, Laitila, L, Piippo, H, Hammaren, M, Parikka, M, Haikarainen, T.Show

Microbiol Spectr ? e0004926 e0004926 (2026)

PMID: 42446239 DOI: 10.1128/spectrum.00049-26

Primary Citation of related structures

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