ISDA: 9TLO

Deposition Date 2025-12-11

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

9TLO

Keywords:

DE NOVO PROTEIN

Title:

De novo designed single-chain antiparallel coiled-coil hairpin with binding site for BCL-xL, Sc-apCC-2-BCL-xL-5

Biological Source:

Source Organism(s):

synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli 'bl21-gold(de3)plyss ag'

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.20 Å

R-Value Free:

0.24

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 43 21 2

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Sc-apCC-2-BCL-xL-5
Chain IDs:A, B, C
Chain Length:75
Number of Molecules:3
Biological Source:synthetic construct

Ligand Molecules

GOL

Primary Citation

De Novo-Designed Bifunctional

Mylemans, B, Korona, B, Acevedo-Jake, A.M, MacRae, A, Edwards, T.A, Huang, D.T, Wilson, A.J, Itzhaki, L.S, Woolfson, D.N.Show

J.Am.Chem.Soc. ? ? ? (2026)

DOI: 10.1021/jacs.6c07593

Primary Citation of related structures

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