ISDA: 9TLG

Deposition Date 2025-12-10

Release Date 2026-08-12

Last Version Date 2026-08-12

Entry Detail

PDB ID:

9TLG

Keywords:

BLOOD CLOTTING

Title:

Structure of human prothrombinase with meizothrombin

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli, Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.10 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Coagulation factor V heavy ch
Chain IDs:A
Chain Length:709
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Coagulation factor V light ch
Chain IDs:B
Chain Length:651
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Activated factor Xa heavy cha
Mutagens:E129N, S130E, T132K, K134D, N166H, K169M, S173D, I175R, S195A, A233R, D239K
Chain IDs:C (auth: H)
Chain Length:254
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Coagulation factor X
Mutagens:T85M, S90R, L91A, D92F, H101K, E102R, E103V, N105S
Chain IDs:D (auth: L)
Chain Length:110
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Prothrombin
Chain IDs:E (auth: P)
Chain Length:320
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Prothrombin
Chain IDs:F (auth: Q)
Chain Length:259
Number of Molecules:1
Biological Source:Homo sapiens

Modified Residue