ISDA: 9THK

Deposition Date 2025-12-03

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9THK

Keywords:

MEMBRANE PROTEIN

Title:

Structure of human CLN8 in an apo-state

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Saccharomyces cerevisiae

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.60 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Protein CLN8
Gene (Uniprot):CLN8
Chain IDs:A (auth: B), B (auth: D)
Chain Length:293
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9UBY8 Pfam ID:PF03798

Ligand Molecules

COA

Primary Citation

Stereospecific GPG acylation by CLN8 drives BMP biosynthesis and underpins Batten disease

Sheokand, P.K, Lacabanne, D, James, A.M, Ruprecht, J.J, van der Kleij, J, Muller-Niva, J, Salo, M.H, Juneja, N, Jenkins, J, Shun Yu, C, Pratt, M.A, King, M.S, Weimer, J.M, Koulman, A, Hinttala, R, Santorelli, F.M, Murphy, M.P, Kunji, E.R.S, Petkevicus, K.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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