ISDA: 9T1T

Deposition Date 2025-10-22

Release Date 2026-11-04

Last Version Date 2026-11-04

Entry Detail

PDB ID:

9T1T

Keywords:

HYDROLASE

Title:

Crystal Structure of the correct enantiomer bound to the PH domain of Btk

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.96 Å

R-Value Free:

0.36

R-Value Work:

0.29

R-Value Observed:

0.29

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Tyrosine-protein kinase BTK
Gene (Uniprot):BTK
Chain IDs:A, B (auth: C), C (auth: G), D (auth: J)
Chain Length:169
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q06187 EC:2.7.10.2

Ligand Molecules

A1JS0

Primary Citation

Inhibition of a Pleckstrin Homology Domain by Lysine-reactive Covalent Inhibitor

Brear, P, West, R.M, Nicolescu, R.C.B, Blaszczyk, B.K, Deingruber, T, Sanders, M.G, Perez-Areales, F.J, Spring, D.R, Hyvonen, M.Show

To be published ? ? ? (?)

Primary Citation of related structures

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