9T1P image
Deposition Date 2025-10-21
Release Date 2026-07-08
Last Version Date 2026-07-08
Entry Detail
PDB ID:
9T1P
Keywords:
TRANSFERASE
Title:
Human PI3Kdelta in complex with IOA-288
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Bos taurus (Taxon ID: 9913)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.97 Å
R-Value Free:
0.27
R-Value Work:
0.21
R-Value Observed:
0.22
Space Group:
P 21 21 21
9T1P validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Phosphatidylinositol 4,5-bisp
Gene (Uniprot):PIK3CD
Chain IDs:A
Chain Length:1044
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O00329 Pfam ID:PF02192, PF00794, PF00792, PF00613, PF00454 EC:2.7.1.137
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Phosphatidylinositol 3-kinase
Gene (Uniprot):PIK3R1
Chain IDs:B
Chain Length:169
Number of Molecules:1
Biological Source:Bos taurus
UniProt ID:P23727 Pfam ID:PF16454
Ligand Molecules
A1JS2
Primary Citation
Roginolisib selectively inhibits PI3Kdelta by stabilizing the C-terminal helix kalpha12
To Be Published ? ? ? (?)
Primary Citation of related structures
9T07
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