ISDA: 9T00

Deposition Date 2025-10-16

Release Date 2026-08-12

Last Version Date 2026-08-12

Entry Detail

PDB ID:

9T00

Keywords:

BLOOD CLOTTING

Title:

Crystal structure of prethrombin-2 with a peptide corresponding to the C-terminus of the heavy chain of factor Va

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.80 Å

R-Value Free:

0.30

R-Value Work:

0.25

Space Group:

P 1

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Prothrombin
Mutagens:S525A
Chain IDs:A, C
Chain Length:314
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Coagulation factor V heavy ch
Chain IDs:B, D
Chain Length:24
Number of Molecules:2
Biological Source:Homo sapiens

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
PTR	B	TYR	modified residue

Primary Citation

Prothrombinase processivity is conferred by substrate allostery.

Ustok, F.I, Faille, A, Warren, A.J, Huntington, J.A.Show

Embo J. 45 3954 3977 (2026)

PMID: 42020574 DOI: 10.1038/s44318-026-00782-4

Primary Citation of related structures

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