9SYN image
Deposition Date 2025-10-13
Release Date 2026-03-11
Last Version Date 2026-03-11
Entry Detail
PDB ID:
9SYN
Keywords:
TRANSCRIPTION
Title:
Crystal structure of TEAD4 in complex with Vgll1-peptide and IAG933
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.30 Å
R-Value Free:
0.23
R-Value Work:
0.20
R-Value Observed:
0.20
Space Group:
P 21 21 21
9SYN validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Transcriptional enhancer fact
Gene (Uniprot):TEAD4
Chain IDs:A
Chain Length:220
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q15561 Pfam ID:PF17725
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Transcription cofactor vestig
Gene (Uniprot):Vgll1
Chain IDs:B
Chain Length:18
Number of Molecules:1
Biological Source:Mus musculus
UniProt ID:Q99NC0 Pfam ID:PF07545
Ligand Molecules
MYR
WCF
Primary Citation
Discovery of Clinical Candidate IAG933, a Potent YAP-TEAD PPI Disrupter.
J.Med.Chem. ? ? ? (2026)
PMID: 41780024 DOI: 10.1021/acs.jmedchem.5c03009
Primary Citation of related structures
9SYN
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