9SVN image
Deposition Date 2025-10-03
Release Date 2026-08-26
Last Version Date 2026-08-26
Entry Detail
PDB ID:
9SVN
Keywords:
Title:
Structure of dihydrofolate reductase from Burkholderia thailandensis (I99L variant) complexed with trimethoprim and dihydrofolate
Biological Source:
Source Organism(s):
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.19 Å
R-Value Free:
0.24
R-Value Work:
0.21
R-Value Observed:
0.21
Space Group:
P 3 1 2
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Dihydrofolate reductase
Mutagens:I99L
Chain IDs:A, B, C, D, E
Chain Length:169
Number of Molecules:5
Biological Source:Burkholderia thailandensis
Primary Citation
Evolutionary Convergence on a Dihydrofolate Reductase Mutation Drives Trimethoprim-Sulfamethoxazole Resistance in Burkholderia thailandensis.
Acs Infect Dis. 12 2627 2641 (2026)
PMID: 42599400 DOI: 10.1021/acsinfecdis.5c01132
Primary Citation of related structures
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