9SVM image
Deposition Date 2025-10-03
Release Date 2026-08-26
Last Version Date 2026-08-26
Entry Detail
PDB ID:
9SVM
Keywords:
OXIDOREDUCTASE
Title:
Structure of dihydrofolate reductase from Burkholderia thailandensis complexed with trimethoprim and dihydrofolate
Biological Source:
Source Organism(s):
Burkholderia thailandensis (Taxon ID: 57975)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.84 Å
R-Value Free:
0.23
R-Value Work:
0.20
R-Value Observed:
0.21
Space Group:
C 1 2 1
9SVM validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Dihydrofolate reductase
Chain IDs:A
Chain Length:169
Number of Molecules:1
Biological Source:Burkholderia thailandensis
Ligand Molecules
NDP
SO4
TOP
Primary Citation
Evolutionary Convergence on a Dihydrofolate Reductase Mutation Drives Trimethoprim-Sulfamethoxazole Resistance in Burkholderia thailandensis.
Acs Infect Dis. 12 2627 2641 (2026)
PMID: 42599400 DOI: 10.1021/acsinfecdis.5c01132
Primary Citation of related structures
9SVN
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