9SUN image
Deposition Date 2025-09-29
Release Date 2026-10-07
Last Version Date 2026-10-07
Entry Detail
PDB ID:
9SUN
Keywords:
LIGASE
Title:
Crystal structure of CRBN-midi in complex with 1-(1-(piperidin-4-yl)-1H-indol-4-yl)dihydropyrimidine-2,4(1H,3H)-dione
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.36 Å
R-Value Free:
0.29
R-Value Work:
0.23
R-Value Observed:
0.23
Space Group:
P 1 21 1
9SUN validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein cereblon
Gene (Uniprot):CRBN
Chain IDs:A, B (auth: C)
Chain Length:329
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q96SW2
Ligand Molecules
A1JP8
ZN
Primary Citation
Structural and Biophysical Methods for the Assessment of Cereblon Binders for PROTACs
To Be Published ? ? ? (?)
Primary Citation of related structures
9SUN
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