ISDA: 9SRW

Deposition Date 2025-09-25

Release Date 2026-07-22

Last Version Date 2026-07-22

Entry Detail

PDB ID:

9SRW

Keywords:

DNA BINDING PROTEIN

Title:

Cryo-EM structure of the Mlc tetramer in complex with the anti-repressor MtfA

Biological Source:

Source Organism(s):

Escherichia coli (Taxon ID: 562)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.30 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA-binding transcriptional r
Gene (Uniprot):mlc
Chain IDs:B (auth: A), C (auth: B), E (auth: C), F (auth: D)
Chain Length:455
Number of Molecules:4
Biological Source:Escherichia coli

UniProt ID:P50456 Pfam ID:PF00480

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mlc titration factor A
Gene (Uniprot):mtfA
Chain IDs:A (auth: E), D (auth: F)
Chain Length:287
Number of Molecules:2
Biological Source:Escherichia coli

UniProt ID:P76346 Pfam ID:PF06167 EC:3.4.11.-

Ligand Molecules

Primary Citation

Structural basis of Mlc-mediated transcriptional regulation of carbohydrate metabolism.

Roth, P, Fender, I, Jeckelmann, J.M, Ucurum, Z, Lemmin, T, Fotiadis, D.Show

Nat Commun ? ? ? (2026)

PMID: 42436118 DOI: 10.1038/s41467-026-75270-8

Primary Citation of related structures

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